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Loss in Y chromosome puts men at higher cancer risk: Research

London, Tue, 29 Apr 2014 NI Wire

In a major breakthrough, a unique fact has been established which indicates that loss of Y chromosome could explain shorter life expectancy and higher cancer risk for men.

According to researchers at Uppsala University in Sweden, a correlation between a loss of the Y chromosome in blood cells and both a shorter life span and higher mortality from cancer in other organs.

Lars Forsberg, a researcher at department of immunology, genetics and pathology at Uppsala University, said, "Men who had lost the Y chromosome in a large proportion of their blood cells had a lower survival, irrespective of cause of death. We could also detect a correlation between loss of the Y chromosome and risk of cancer mortality."

To reach this conclusion, researchers analysed the DNA in blood samples from a group of more than 1,600 elderly men. They found that the most common genetic alteration was a loss of the Y chromosome in a proportion of the white blood cells.

The group of men was studied for several years and the researchers could detect a correlation between the loss of the Y chromosome and shorter survival. The results indicate that the Y chromosome has a role in tumour suppression and they might explain why men get cancer more often than women.

"We believe that analyses of the Y chromosome could in the future become a useful general marker to predict the risk for men to develop cancer", added Jan Dumanski, a professor at Uppsala University.

(With inputs form IANS)

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