In a recent research, researchers have identified six proteins in spinal fluid, which could be used as markers for the illness.
Katarina Kagedal, reader in Experimental Pathology at Linkoping University, said that in the patients of Alzheimer's, some mechanism happens in the lysosomes, which make them unable to manage the extra amount of beta amyloid.
She further added that they fill up with junk, which are usually broken down into its component parts and recycled.
According to the hypothesis of researchers these changes in the brain's lysosomal network could be reflected in the spinal fluid, which surrounds the brain's various parts and drains down into the spinal column.
The researchers studied samples of spinal marrow from 20 Alzheimer's patients and an equal number of healthy people with no signs of Alzheimer's. The screening was focused at 35 proteins that are associated with the lysosomal network.
Kagedal said that that six of these showed clear increase among the patients; however, none of them were previously known as markers for Alzheimer's.
The study was conducted on 20 unknown, archived spinal marrow samples and the results were concluded afterwards on an independent range of samples of equal size.
The story has been published in Neuromolecular Medicine.
With inputs from ANI
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