Washington, January 2 (ANI): Ingestion of glucose but not fructose reduces cerebral blood flow and activity in brain regions that regulate appetite, and ingestion of glucose but not fructose produces increased ratings of satiety and fullness, researchers say.
In the study, researchers sought out to examine possible factors regarding the associations between fructose consumption and weight gain.
"Increases in fructose consumption have paralleled the increasing prevalence of obesity, and high-fructose diets are thought to promote weight gain and insulin resistance. Fructose ingestion produces smaller increases in circulating satiety hormones compared with glucose ingestion, and central administration of fructose provokes feeding in rodents, whereas centrally administered glucose promotes satiety," background information in the article said.
"Thus, fructose possibly increases food-seeking behaviour and increases food intake." How brain regions associated with fructose- and glucose-mediated changes in animal feeding behaviours translates to humans is not completely understood," it said.
Kathleen A. Page from Yale University School of Medicine, New Haven, Conn., and colleagues conducted a study to examine neurophysiological factors that might underlie associations between fructose consumption and weight gain.
The study included 20 healthy adult volunteers who underwent two magnetic resonance imaging sessions in conjunction with fructose or glucose drink ingestion. The primary outcome measure for the study was the relative changes in hypothalamic regional cerebral blood flow (CBF) after glucose or fructose ingestion.
The researchers found that there was a significantly greater reduction in hypothalamic CBF after glucose vs. fructose ingestion.
"Glucose but not fructose ingestion reduced the activation of the hypothalamus, insula, and striatum-brain regions that regulate appetite, motivation, and reward processing; glucose ingestion also increased functional connections between the hypothalamic-striatal network and increased satiety," the researchers said.
"The disparate responses to fructose were associated with reduced systemic levels of the satiety-signaling hormone insulin and were not likely attributable to an inability of fructose to cross the blood-brain barrier into the hypothalamus or to a lack of hypothalamic expression of genes necessary for fructose metabolism," they added.
The study has been recently published in JAMA. (ANI)
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