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Protein biomarkers in exhaled air to help detect lung cancer early

Washington, Thu, 03 Feb 2011 ANI

Washington, Feb 3 (ANI): The earlier a tumour can be detected, the greater the chance of healing the patient. But early diagnosis is often difficult in many cases.


In its initial stages, the tumour-related complaints resemble chronic inflammatory reactions.


Now, researchers at the Fraunhofer Institute for Cell Therapy and Immunology IZI and the University Clinic in Leipzig are developing a new diagnostics platform which could detect the illness in its early stages - protein biomarkers in exhaled air that divulge the presence of pathological cells in the lung.


They want to produce a first prototype that can then be further developed into a diagnostic tool that can be used in practice.


"Since 2006, working with the working groups of Professor Hubert Wirtz and Professor Ulrich Sack of the University Clinic, we first identified various biomarkers that are particularly well-suited for the identification of lung-cancer cells," said Jorg Lehmann, head of the Cell Engineering/GLP Unit at IZI.


"The main difficulty lies in finding a reliable way to distinguish cancer from chronic inflammatory disease," he added.


The researchers have developed a laboratory method for reliably identifying biomarkers specific to lung cancer in special samples of exhaled air.


To accomplish this, the patient must breathe into a piece of equipment for roughly 20 minutes. The exhaled breath condensate is then evaporated.


Biomarkers are detected by means of special antibodies that recognize substances such as the protein VEGF.


This protein is responsible for stimulating the growth of new blood vessels.


This laboratory method is still too 'elaborate and expensive' for normal everyday use, said Lehmann.


In their new testing platform, the researchers have actually applied two new developments: in addition to the method enlisting protein biomarkers to identify cancer cells, they also make use of the antibody specially developed for this procedure.


This way, within just a few years, every physician investigating a suspicion of lung cancer can use the diagnostic platform right in his or her practice to test whether there really is a tumour and quickly initiate treatment. (ANI)


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