Washington, August 16 (ANI): Expectant mothers who drink a large glass of wine a day stunt their children's growth up to the age of nine, a new study on the effects of heavy prenatal alcohol exposure (PAE) on growth and body composition throughout childhood has found.
"This study is the first to examine the effects of heavy PAE on growth in a single cohort over time using a more rigorous single statistical model with repeated measures for each outcome," R. Colin Carter, corrsdponding author of the study from Harvard Medical School, said.
"Our research adds to prior findings of fetal alcohol-related growth restriction in childhood by demonstrating that the effects of alcohol exposure on somatic growth are largely determined in utero. In addition, this study is the first to examine the effects of PAE on percent body fat," he said.
Carter and his colleagues recruited two groups of pregnant women at their initiation of prenatal care at an urban obstetrical clinic in Cape Town, South Africa - 85 heavy-drinking women, defined as two or more drinks/day or four or more drinks/occasion, and 63 abstaining and light-drinking women, defined as less than one drink/day and no binge drinking.
The women were interviewed during their pregnancies about alcohol, smoking, drug use, and demographics.
Their children had their length/height, weight, and head circumference measured at 6.5 and 12 months, and again at five and nine years of age.
"We found that children born to women who drank heavily during pregnancy had reductions in weight, height, and head circumference when compared with children without heavy PAE," Carter said.
"This alcohol-related growth restriction was present in early infancy and persisted through to nine years of age. What is important is that these effects were exacerbated by iron deficiency in infancy.
"By contrast, iron deficiency at five years of age and food security did not impact the effects of alcohol on growth. Infants with heavy PAE also had a delay in weight gain at 12 months of age. In addition, the most alcohol-affected children, those with fetal alcohol syndrome (FAS) and partial FAS (PFAS), had leaner body composition when compared with children without these diagnoses," he said.
According to Carter, the persistence of smaller weight, height, and head circumference, an indicator of brain growth, suggest that these effects may be permanent and are potentially markers of later cognitive development.
"These effects may be detrimental to the children as growth deficits have been shown to be related to other health problems, such as lower IQ," he said.
"Furthermore, the effects of alcohol on growth were much more severe if the child had iron deficiency anemia as an infant, a condition that is common in the US and worldwide," Carter said.
The study will be published in Alcoholism: Clinical and Experimental Research. (ANI)
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