Washington, July 18 (ANI): Scientists have identified the critical role of a receptor called c-Kit in the development and function of insulin-producing beta cells, making it an exciting therapeutic target for the management of diabetes.
A collaboration of scientists from Western University in London, Canada and the Children's Health Research Institute, an Institute within the Lawson Health Research Institute made the research possible.
The research, led by Rennian Wang, demonstrated that overexpression of c-Kit not only leads to increased insulin production but also counteracts the early diabetic effects of a high-fat diet.
Diabetes is one of the most common metabolic diseases affecting millions of people. It's associated with a multitude of complications leading to considerable morbidity and a major medical as well as financial burden on society.
One of the major defects in diabetes is the loss of beta cells in the pancreatic islet.
Wang and colleagues, including Zhi Chao Feng, a PhD candidate and first author on the paper, developed a transgenic mouse model (c-Kit Wv) that overexpressed c-Kit, specifically in beta cells.
"When c-Kit is overexpressed, we observed a significant improvement in beta cell function and survival," said Wang, a Professor in the Departments of Physiology and Pharmacology, and Medicine at Western's Schulich School of Medicine and Dentistry.
"You can even rescue c-Kit mutant mice from the early onset of diabetes, and protect against high-fat diet-induced beta cell defects. This is a novel finding and is being reported for the first time," Wang noted.
Wang believes ongoing research into c-Kit and its underlying mechanisms, will pave the way to develop strategies to preserve and restore function to beta cells as a cure for both type 1 and type 2 diabetes.
The findings have been published in the August issue of Diabetologia, and featured in the Research Highlights in Nature Reviews Endocrinology (June 5). (ANI)
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