Corticosteroids 'ineffective for acute sinusitis'

Washington, August 8 (ANI): Corticosteroids, frequently prescribed to alleviate acute sinusitis, show no clinical benefit in treating the condition, scientists found in a randomized controlled trial.

The common cold is the main cause of acute sinusitis, which is characterized by inflammation of the nasal cavities, blocked nasal passages and sometimes headaches and facial pain.

Allergies and bacteria can also cause the condition, which is uncomfortable and difficult to treat. Antibiotics are a common treatment, despite the fact that the cause is often viral and will not respond to antibiotics. Corticosteroids are increasingly being used to alleviate symptoms, although the evidence for efficacy is inconclusive.

To determine the effectiveness of oral corticosteroids on acute rhinosinusitis (sinusitis), researchers from the Netherlands conducted a randomized, double-blind controlled trial involving 174 adults with clinically diagnosed acute rhinosinusitis.

Eighty-eight patients were randomized to a group that received 30 mg/d of prednisolone for a week and the remaining 86 received placebo. In the prednisolone group, 55 of 88 patients reported that their facial pain or pressure had resolved by day 7, versus 48 of 86 in the placebo group. Although there was a slight reduction of facial pain in the prednisolone group, the results were neither statistically nor clinically significant. Moreover, other patient-relevant outcomes revealed similar results.

"We found no clinically relevant effect of systemic corticosteroid monotherapy among patients with clinically diagnosed, uncomplicated acute rhinosinusitis," wrote Dr. Roderick Venekamp, University Medical Centre Utrecht, Utrecht, the Netherlands, with co-authors.

"There is no rationale for the use of corticosteroids in the broad population of patients with clinically diagnosed acute rhinosinusitis.

"Future studies should focus on identifying subgroups of patients who may benefit from intranasal or systemic corticosteroid treatment," they concluded.

The research was published in CMAJ (Canadian Medical Association Journal). (ANI)